Anasarca, or extreme generalized edema, is a medical condition characterised by widespread swelling of the skin due to effusion of fluid into the extracellular space.
It is usually caused by liver failure (cirrhosis of the liver) or renal failure/disease and severe malnutrition/protein deficiency. The increase in salt and water retention caused by low cardiac output can also result in anasarca as a long term maladaptive response.
It can also be created from the administration of exogenous
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