Amphetamine dependence refers to a state of dependence on a drug in the amphetamine class.
Tolerance is developed rapidly in amphetamine abuse, thereby the amount of the drug that is needed to satisfy the addiction needs to be increased at regular intervals.
Conversely, some researchers have reported observing the opposite effect in animal models: repeated amphetamine use can produce reverse tolerance or sensitization to the psychological or locomotor-stimulating effects of the drug. Development of
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